Identify a common signature to SAID enabling rapid differential diagnosis
Provide deep characterization of each specific pathogenic pathway and build dedicated analysis kits
Build a robust algorithm enabling reliable triage among the whole SAID spectrum
Now the number of COVID-19 patients has reduced significantly, the hospitals can again focus on their core activities. Already activated sites are able to recruit patients again and new sites are being opened.
An intriguing elevated number of Kawasaki disease cases, a rare inflammatory disorder, are recently noticed. The current pandemic context clearly questions a possible link between the SARS-CoV-2 virus, and the Kawasaki disease phenotype.
The concept of autoinflammatory disorders was introduced by Daniel Kastner in 1999 (Michael McDermott was 1st author). Since then, characterization of these conditions has been continuously refined. After 20 years, McDermott, Caseley and Savic have advocated for a systems-based classification of the systemic autoinflammatory diseases (SAIDs) which defines the complex interplay of molecular mechanisms, and systems, at the heart of many monogenic and polygenic conditions.
Six centres are ready to enroll SAID patients in France. The opening of other French centres is foreseen in the coming weeks together with centres in other countries, such as Spain and Slovenia to start with. The real work begins!
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Grant agreement no: 779295
Funded under: H2020-EU.3.1.1.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 779295
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